The main areas of research and teaching of Dr. Santillán-Salgado include financial economics, corporate finance, international finance, valuation of assets with risk and risk management. He has widely published on economic and financial issues. His book "La Gran Recesión (2007-2012): Lecciones y Oportunidades para México", was published by EGADE and the Foundation for Research of the Mexican Institute of Finance Executives.
He has been a researcher at the Colegio de México. He is currently a member of the SNI (Sistema Nacional de Investigadores), Level III, Conacyt and gives lectures at universities in Europe, United States, and South America.